ANTIMICROBIAL RESISTANCE SOLUTIONS
WITH DR. JOHN H. REX
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R&D Insight
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Antimicrobial resistance poses a catastrophic threat. If we don’t act now, any one of us could go into hospital in 20 years for minor surgery and die because of an ordinary infection that can’t be treated by antibiotics. And routine operations like hip replacements or organ transplants could be deadly because of the risk of infection.
Dame Sally Davies Tweet
FDA AMDAC – Developing Single-Pathogen agents for P. aeruginosa and A. baumannii
How hard (and how) to Pull? Net value of Pull via a Transferrable Exclusivity Extension (TEE)
Impact of PASTEUR: 9.9m lives saved, ROI of 125:1
IDSA White Paper on developing narrow-spectrum antimicrobials + editorial by G. Drusano
De-risking vaccine development: Insights spanning decades of experience
Language matters: CRE vs. CPE; SDD vs. I; and MDR, XDR, PDR, UDR vs. DTR
Two new oral drugs for gonorrhea!
Melinta goes bankrupt / Never let a good crisis go to waste
Modeling the value of an effective antibiotic — Megiddo et al.
In Praise of Non-Inferiority
FDA Workshop: Animal Models To Support Antibacterial Development (5 Mar 2020, post-meeting notes)
Developing systemic & inhaled antibiotics for lung infections
The thoughtless person playing with penicillin treatment is morally responsible for the death of the man who succumbs to infection with the penicillin-resistant organism.
Alexander Fleming Tweet
The bipartisan PASTEUR Act is the strongest bill ever written to strengthen antibiotic development and use. It will fix our market failures, expand the pipeline for next generation antibiotics, and save lives. We can’t sit on our hands as this public health crisis arrives – we have to act now.
U.S. Senator Michael Bennet Tweet